I am a tenure-track assistant professor of Biostatistics and Bioinformatics, and Human Genetics at Emory University. My research develops and applies statistical methodologies to understand disease mechanisms using single-cell genomics and genetics data. I focus on gene network inference and the genetic basis of single-cell genomics, with the goal of mapping cell-type-specific gene regulatory networks and elucidating genetic mechanisms of complex diseases through network-based approaches.
My methodological research is driven by challenges in human disease and by collaborative research, with a particular focus on Alzheimer’s disease as well as lung and immune-related conditions. My work has been published in leading journals across statistics and the life sciences, including Journal of the American Statistical Association, Journal of the Royal Statistical Society, Nature Communications, and Science Translational Medicine. My research is supported by NIH funding and pilot grants at Emory University.
Prior to Emory, I received my Ph.D. training in Biostatistics at Yale School of Public Health, where I was fortunately co-advised by Dr. Hongyu Zhao and Dr. Zhou Fan.
I am looking forward to working with students on methodology and analysis projects. Feel free to contact me if you are a student interested in single-cell genomics and genetics!
Research interests
Statistical genomics and genetics:
Gene networks
Cell-type-specific analysis
Genetic regulation of gene expression
Statistical methodologies:
High-dimensional network estimation
Latent-variable model
Education
Ph.D. in Biostatistics, 2023
Yale University
B.S. in Statistics, 2018
Sun Yat-sen University
News
Congratulations to Dongsoo Lee, the first-place recipient of the Patel-Naik Award! This award recognizes pre-candidacy PhD students in RSPH BIOS who develop outstanding and innovative research proposals.
scTWAS has been published in Nature Communications! In this work, we developed a powerful statistical method for performing cell-type-specific transcriptome-wide associations studies (TWAS) with single cell data. Big thanks to our wonderful collaborator Zhaotong Lin from Florida State University.
Both Dongsoo Lee and Yutong Liu's abstracts have been accepted as invited talks, and Angela Yu and Weiwei Wu will also present their invited posters at STATGEN 2026. Congratulations, Dongsoo, Yutong, Angela and Weiwei!
Chang received a new pilot award from Emory Goizueta ADRC, which proposes to study the impact of air pollution on aging brain using single-cell transcriptomics.
Email: chang.su@emory.edu
Office: GCR 334, 1534 Clifton Rd, Atlanta, GA 30322